PRP Fillers vs Traditional Dermal Fillers: What’s the Difference?

Loss of volume, hollow under-eyes, or tired-looking skin can make you feel less like yourself, even when you’re doing everything right with your skincare routine. Many people turn to injectables for facial rejuvenation, but choosing between a PRP filler and traditional dermal fillers can feel overwhelming without the right information. Understanding the differences in ingredients, how each option works, and what results to expect can help you make the most informed choice. At Face Forward Regenerative Aesthetics in St. Louis, MO, we offer both PRP bio-fillers and traditional filler options to support your unique goals. Knowing how these treatments compare can help you decide which one aligns with your skin’s needs and your vision for natural-looking results.

What Are Dermal Fillers?

Dermal fillers are widely used in aesthetic medicine to restore lost volume, smooth wrinkles, and sculpt facial features. Most are made with hyaluronic acid (HA), a substance that naturally occurs in the skin and helps retain moisture. These fillers provide immediate plumping effects and are ideal for creating a refreshed, more youthful appearance.

How Traditional Fillers Work

Once injected, HA-based dermal fillers bind to water molecules in the skin, instantly filling in hollow areas and softening lines. The results are visible right away and typically last between 6 and 18 months, depending on the product and placement. Over time, the body naturally metabolizes the filler.

Common Uses of Dermal Fillers

Traditional fillers are often used in high-movement or volume-depleted areas of the face, including:

  • Cheeks and mid-face
  • Nasolabial folds
  • Lips
  • Chin and jawline
  • Under-eye hollows (tear troughs)

These injections are favored for their quick results and minimal downtime.

What Is a PRP Filler or Bio-Filler?

A PRP filler, also known as a biofiller or PRP bio-filler, is a regenerative treatment that uses your own blood to restore volume and improve skin quality. The process begins by drawing a small amount of your blood, which is then processed to separate platelet-rich plasma (PRP). This PRP is transformed into a gel-like substance that acts as a natural filler. Some providers also enhance this approach by combining PRP with hyaluronic acid to create a biostimulator that encourages collagen production and tissue regeneration. Unlike synthetic fillers, PRP fillers offer a more natural way to rejuvenate the skin, with subtle results that develop and improve over time.

How PRP Bio-Fillers Are Made

The treatment begins with a simple blood draw. Your blood is then spun in a centrifuge to isolate the PRP, which is processed into a gel-like substance. This PRP bio filler is carefully injected into target areas to promote tissue regeneration, improve volume, and support collagen production. Since the material comes from your own body, the risk of allergic reaction is very low.

What Makes PRP Fillers Different

Unlike traditional fillers that offer immediate volume, PRP fillers work gradually. They stimulate your skin to produce collagen and elastin, improving overall texture, firmness, and tone. The results are more subtle at first, but they continue to improve naturally over time, making this treatment a favorite for long-term skin health.

Best Areas for PRP Fillers

PRP is particularly beneficial in areas where the skin is thin or prone to damage. Common injection sites include:

  • Under-eye hollows (bio filler under eyes)
  • Cheeks and mid-face
  • Jawline and temples

These zones respond well to the regenerative effects of PRP, making it an ideal facial rejuvenation tool for delicate features.

Key Differences Between PRP Fillers and Traditional Fillers

While both filler types can enhance your appearance, they do so in very different ways. Understanding these key differences can help you determine which is better suited to your skin’s needs.

Ingredients & Source

  • Dermal Fillers: Made from synthetic hyaluronic acid
  • PRP Fillers: Created from your own platelet-rich plasma

Results Timeline & Longevity

  • Dermal Fillers: Provide instant results that can last 6 to 18 months
  • PRP Bio-Fillers: Offer gradual improvements over 4 to 8 weeks with benefits lasting up to a year or more

Skin Health & Rejuvenation Benefits

  • Dermal Fillers: Primarily restore volume and contour without affecting skin quality
  • PRP Fillers: Improve skin texture, elasticity, and overall health by stimulating collagen

Ideal Candidates & Skin Types

  • Dermal Fillers: Great for those wanting fast, dramatic results
  • PRP Bio-Fillers: Ideal for patients who prefer a natural approach and long-term skin regeneration

Pros and Cons of PRP Fillers

Choosing the right filler often comes down to weighing the pros and cons of each option based on your skin goals and preferences.

Benefits of PRP Bio-Fillers

  • Uses your body’s own regenerative material
  • Improves tone, texture, and elasticity
  • Minimizes risk of allergic reaction
  • Produces gradual, natural-looking results
  • Can be safely combined with other treatments

Limitations to Consider

  • Results are not immediate
  • Multiple sessions may be needed
  • Not recommended for individuals with certain blood conditions

Which Filler Option Is Right for You?

The right filler treatment depends on your individual goals, preferences, and how quickly you’d like to see results. If you’re seeking immediate volume and contouring, traditional dermal fillers made with hyaluronic acid may be the better fit. For those looking for a gradual, natural transformation that supports long-term skin health, PRP fillers offer a regenerative approach that stimulates collagen and enhances skin quality over time. Some individuals choose to combine both treatments, using hyaluronic acid for structural enhancement and PRP for overall facial rejuvenation and skin improvement. A personalized consultation with a qualified aesthetic provider can help determine the best approach based on your skin type, concerns, and desired outcome.

Start Your Natural Skin Rejuvenation with PRP Fillers

Not every patient is looking for instant change. For those who value natural results, long-term skin improvement, and subtle volume enhancement, PRP filler treatments are a powerful option. As a trusted facial rejuvenation tool, PRP encourages your body to restore itself from within, helping you achieve a refreshed, radiant look without relying on synthetic substances.

Why Choose Face Forward Regenerative Aesthetics for BioFillers in St. Louis, MO

At Face Forward Regenerative Aesthetics in St. Louis, MO, our focus is on regenerative, science-driven care that supports lasting beauty. Led by Molly Bailey, PA-C, who brings over a decade of experience in aesthetic medicine and plastic surgery, our practice offers a highly personalized approach that blends precision and artistry.

We welcome patients from across St. Louis and neighboring communities such as Webster Groves, Clayton, Brentwood, and Kirkwood. Whether you’re new to biofillers or ready to switch to a more natural treatment path, our team is here to guide you with expert care and customized solutions. See real patient results and explore how PRP fillers can support your journey toward healthier skin.

Book an Appointment Today!

Refresh your skin with personalized PRP filler treatments at Face Forward Regenerative Aesthetics in St. Louis, MO. Visit us at 9840 Clayton Rd, St. Louis, MO 63124, or call (314) 417-9017 to schedule your appointment. You can also book your consultation online to explore the most natural way to restore volume and skin vitality.

Get in Touch

Get in Touch